• Normal Esophagus - The esophagus is a muscular tube serving as a conduit for ingested nutrients to travel to the stomach where digestion begins. However it is more than a simple conduit. The surrounding circular and longitudinal smooth muscles contract in a coordinated fashion to propel food boluses to the stomach. Defects in smooth muscle contraction can lead to swallowing disorders known as dysphagia-difficulty swallowing
  • Layers of the esophagus - The esophagus is lined by a multilayered squamous epithelium. Unlike in humans, this epithelium is keratinized due to the course diet of the mice. Below the epithelium is the submucosa, connecting the mucosa (epithelium) with underlying structures. The submucosa is typically very vascular and inhumans (but not mice) contains exocrine glands secreting mucins to lubricate passage of food boluses.
  • Multilayered epithelium - The multilayered squamous epithelium in the esophagus is structurally similar to epithelium in the oral cavity, skin, and other organs. The basal layer is the first layer of cells and where stem cells are thought to reside for this tissue. Cell proliferation and differentiation occur in the suprabasal layers, as cells migrate upward from the basal compartment toward the lumen. The superficial layer is comprised of fully differentiated, non proliferating keratinocytes. In mice this layer is keratinized due to the course diet consumed by the mice.

John Lynch

Pages in category "Esophagus"

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