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Intestinal Crypt Fission

  • Villi – .5-1.5mm fingerlike projections of the mucosa that augment surface area for absorption
  • Goblet Cells – Unicellular glands that secrete mucus to protect and lubricate epithelial surface
  • Paneth Cells – Provide a niche and secrete growth
  • Intestinal Crypt Fission
  • Small Intestine Epithelium 10X
  • Small Intestine Epithelium 20X
factors for CBC stem cells and antimicrobial proteins for host defense.
  • Crypts of Lieberkühn – The site for stem cells and rapidly proliferating transit amplifying cells. As daughter cells differentiate, they gradually migrate upwards towards the surface epithelium.
  • Crypt Fission – The splitting of two crypts
  • Muscularis Mucosae – A thin layer of smooth muscle just below the crypts
  • CBC (Crypt Base Columnar) Stem Cells - Pluripotent stem cells located between Paneth cells that can symmetrically divide to give rise to daughter CBC cells or which can differentiate into various epithelial lineages in the small intestine.

Small Intestine Epithelium 10X

  • Villi – .5-1.5mm fingerlike projections of the mucosa that augment surface area
  • Goblet Cells – Unicellular glands that secrete mucus to protect and lubricate epithelial surface
  • Paneth Cells – Provide a niche and secrete growth factors for CBC cells
  • Crypts of Lieberkühn – The site for stem cells and rapidly proliferating transit amplifying cells. As daughter cells differentiate, they gradually migrate upwards towards the surface
  • Muscularis Mucosae – A thin layer of smooth muscle just below the crypts
  • Submucosa – A layer of dense connective tissue that joins the smooth muscle (MM) to the mucosa

Small Intestine Epithelium 20X

  • Villi – .5-1.5mm fingerlike projections of the mucosa that augment surface area
  • Goblet Cells – Unicellular glands that secrete mucus to protect and lubricate epithelial surface
  • Paneth Cells – Provide a niche and secrete growth factors for CBC cells
  • Microvilli – Increase the surface area of the intestine to aid absorption
  • Muscularis Mucosae – A thin layer of smooth muscle just below the crypts
  • CBC (Crypt Base Columnar) Stem Cells - Pluripotent stem cells located between Paneth cells that can symmetrically divide to give rise to daughter CBC cells or which can differentiate into various epithelial lineages in the small intestine.

Histologic identification of Paneth cells in the small intestine crypt.

  • Paneth cells can be identified by immunohistochemistry or immunofluorescence for lysozyme
  • Paneth cell granules are detected with phyloxine/tartrazine staining.
  • Transmission electron microscopy can identify Paneth cell granuels and crypt base columnalr cells identified as intestinal stem cells.


Amar Patel and John P. Lynch

Pages in category "Small Intestine"

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