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Small Intestine - Pathology

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Intestinal Polyp in Min Mouse

  • Min (Multiple Intestinal Neoplasia) mouse model for intestinal neoplasia - These mice contain a mutation in exon 850 of the APC gene. The mutation causes the formation of many intestinal adenomatous polyps and less commonly colonic tumors, so the mouse is a useful model for studying intestinal neoplasia.
  • Villi – .5-1.5mm fingerlike projections of the mucosa that augment surface area
  • Crypts of Lieberkühn – The site for stem cells and rapidly proliferating transit amplifying cells. As daughter cells differentiate, they gradually migrate upwards towards the surface epithelium.
  • Polyp – A tumorous growth projecting from the mucus membrane. It is often found in the gastrointestinal tract.
    • Intestinal Polyp in Min Mouse
    • Early Polyp in Min Mouse
    • Intestinal Polyp in Min Mouse 2
  • Muscularis Mucosae – A thin layer of smooth muscle just below the crypts
  • Pathological Crypts –Abnormally growing crypts that are believed to be the first stage in polyp formation

Early Polyp in Min Mouse

  • Villi – .5-1.5mm fingerlike projections of the mucosa that augment surface area
  • Polyp – A tumorous growth projecting from the mucus membrane. It is often found in the gastrointestinal tract.
  • Pathological Cells – Abnormal, diseased cells that may develop into tumors
  • Muscularis Mucosae – A thin layer of smooth muscle just below the crypts
  • Crypts –The site for stem cells and rapidly proliferating transit amplifying cells

Intestinal Polyp in Min Mouse 2

  • Villi – .5-1.5mm fingerlike projections of the mucosa that augment surface area
  • Polyp – A tumorous growth projecting from the mucus membrane. It is often found in the gastrointestinal tract.
  • Pathological Cells – Abnormal, diseased cells that may develop into tumors
  • Muscularis Mucosae – A thin layer of smooth muscle just below the crypts
  • Crypts –The site for stem cells and rapidly proliferating transit amplifying cells

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Pages in category "Small Intestine - Pathology"

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